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Clinical Immunology guides
22 plain-English, evidence-linked guides in Clinical Immunology, with clinical review status shown on each page.
Acquired angioedema management (Management of acquired C1-inhibitor deficiency (AAE-C1-INH))Specialist treatment of acquired angioedema due to C1-inhibitor deficiency, a rare bradykinin-driven swelling disorder that needs different management from allergic swelling and is often linked to an underlying condition.Allergy and immunology testing (Allergy and clinical immunology investigations)Tests used by allergy and immunology specialists to help work out whether symptoms are caused by an allergy or an immune problem, and to guide a safe management plan.Anaphylaxis investigation (Specialist allergy assessment after anaphylaxis)A specialist assessment after a severe, whole-body allergic reaction (anaphylaxis) to try to find the trigger, confirm the diagnosis and plan how to stay safe in future.Autoantibody / autoimmune testing (Autoantibody testing (ANA, ENA, anti-dsDNA, rheumatoid factor and related))Blood tests that look for antibodies the immune system has made against your own body, used to help diagnose and monitor autoimmune conditions such as lupus alongside your symptoms.Autoinflammatory (periodic fever) syndrome assessment (Assessment for autoinflammatory and periodic fever syndromes)A specialist assessment for people with recurrent, unexplained fevers and inflammation, to look for an autoinflammatory (periodic fever) syndrome, which is a problem with the innate immune system rather than ordinary infections.Biologic / immunomodulatory therapy (Biologic and immunomodulatory (immunosuppressive) treatment)Medicines that change how the immune system works, used to treat immune, inflammatory or allergic conditions, given by injection or drip and needing careful screening and monitoring.Chronic urticaria and angioedema assessment (Assessment of chronic urticaria and angioedema)A specialist assessment for people with hives (urticaria) and/or deeper swelling (angioedema) lasting six weeks or more, to find the type, look for triggers and any underlying cause, and plan treatment.Clinical immunology consultation (Clinical immunology specialist consultation)A consultant appointment to investigate problems with the immune system — such as frequent, severe or unusual infections — to find a cause and plan treatment or monitoring.Complement testing (Complement studies (C3, C4, CH50/CH100, AP50))Blood tests that measure complement proteins (such as C3 and C4) and how well the complement system works, used for certain recurrent infections, some autoimmune conditions and unexplained swelling.Connective tissue disease antibody testing (Autoantibody testing for connective tissue (autoimmune rheumatic) disease)Blood tests for autoantibodies, such as ANA, ENA and anti-dsDNA, used to help assess possible connective tissue (autoimmune rheumatic) diseases like lupus, alongside symptoms and examination.Hereditary angioedema diagnosis and management (Hereditary angioedema (HAE) diagnosis and management)Specialist diagnosis and long-term care of hereditary angioedema — an inherited condition causing recurrent deep swelling that does not respond to adrenaline, antihistamines or steroids and needs its own specific treatment and emergency plan.IgG subclass testing (IgG subclasses (IgG1, IgG2, IgG3, IgG4))A blood test that breaks IgG antibody down into its four subclasses (IgG1–IgG4), used selectively when total antibody levels look normal but a specialist still suspects an antibody problem.Immune system blood tests (Immunological investigations (immune function blood tests))A set of blood tests a clinical immunologist may use to find out whether your immune system is working normally, usually when infections are unusually frequent, severe or hard to shift.Immunoglobulin level testing (Quantitative immunoglobulins (serum IgG, IgA, IgM))A blood test that measures the main antibody types — IgG, IgA and IgM — to look for an antibody deficiency or excess, usually when infections are frequent or severe or another condition is suspected.Immunoglobulin replacement therapy (IVIG) (Intravenous immunoglobulin replacement therapy (IVIG))A treatment that replaces missing antibodies using a drip into a vein, given regularly to people with certain immune deficiencies to reduce serious infections.Mastocytosis / mast cell disorder assessment (Assessment for mastocytosis and mast cell activation disorders)A specialist assessment to find out whether symptoms such as flushing, itching, severe allergic reactions or unexplained collapse are caused by a mast cell disorder, including mastocytosis.Primary immunodeficiency diagnosis (Diagnosis of primary immunodeficiency (inborn errors of immunity))A specialist work-up by a consultant immunologist to find out whether an inherited problem with the immune system is causing frequent, severe or unusual infections, and to identify which type.Recurrent infection assessment (Assessment of recurrent, severe, persistent or unusual infections)A specialist assessment for infections that are too frequent, severe, long-lasting or unusual, to find out why and whether the immune system is involved.Secondary immunodeficiency assessment (Assessment of secondary (acquired) immunodeficiency)A specialist assessment to find out whether another illness or its treatment is weakening the immune system, how badly, and what can be done to protect against infection.Subcutaneous immunoglobulin therapy (Subcutaneous immunoglobulin replacement therapy (SCIG))A treatment that replaces missing antibodies through a needle under the skin, often given by the patient at home, to reduce serious infections in people with certain immune deficiencies.Tryptase testing (Serum mast cell tryptase measurement)A blood test that measures tryptase, a marker released by mast cells, used to help look into severe allergic reactions and possible mast cell disorders.Vaccine response testing (Specific antibody response testing (test immunisation))A two-stage blood test that checks whether your immune system can make protective antibodies after a vaccine, used to assess how well your antibody defences actually work.
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